Speeding up tandem mass spectral identification using indexes
نویسندگان
چکیده
منابع مشابه
Building and searching tandem mass spectral libraries for peptide identification.
Spectral library searching is an emerging approach in peptide identifications from tandem mass spectra, a critical step in proteomic data analysis. Conceptually, the premise of this approach is that the tandem MS fragmentation pattern of a peptide under some fixed conditions is a reproducible fingerprint of that peptide, such that unknown spectra acquired under the same conditions can be identi...
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Database searching is the technique of choice for shotgun proteomics, and to date much research effort has been spent on improving its effectiveness. However, database searching faces a serious challenge of efficiency, considering the large numbers of mass spectra and the ever fast increase in peptide databases resulting from genome translations, enzymatic digestions, and post-translational mod...
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MOTIVATION Due to the recent advances in technology of mass spectrometry, there has been an exponential increase in the amount of data being generated in the past few years. Database searches have not been able to keep with this data explosion. Thus, speeding up the data searches becomes increasingly important in mass-spectrometry-based applications. Traditional database search methods use one-...
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Peptide identification by tandem mass spectrometry is the dominant proteomics workflow for protein characterization in complex samples. The peptide fragmentation spectra generated by these workflows exhibit characteristic fragmentation patterns that can be used to identify the peptide. In other fields, where the compounds of interest do not have the convenient linear structure of peptides, frag...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2012
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/bts244